Immune‐instructive scaffolds modulating inflammation to promote bone regeneration
نویسندگان
چکیده
منابع مشابه
Metallic Scaffolds for Bone Regeneration
Bone tissue engineering is an emerging interdisciplinary field in Science, combining expertise in medicine, material science and biomechanics. Hard tissue engineering research is focused mainly in two areas, osteo and dental clinical applications. There is a lot of exciting research being performed worldwide in developing novel scaffolds for tissue engineering. Although, nowadays the majority o...
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1. The structure of bone and the mechanisms for self-repair Bone is one of the most commonly transplanted tissues, with 2.2 million bone grafts performed annually worldwide (Tronci et al., 2013a). Surgeons face a diverse spectrum of clinical challenges in bone reconstruction, and this diversity reflects the variety of anatomic sites, defect sizes, mechanical stresses, and available soft tissue ...
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Background: One of the main challenges with conventional scaffold fabrication methods is the inability to control scaffold architecture. Recently, scaffolds with controlled shape and architecture have been fabricated using 3D-printing. Herein, we aimed to determine whether the much tighter control of microstructure of 3DP PLGA/β-TCP scaffolds is more effective in promoting osteogenesis than por...
متن کاملEngineering Pre-vascularized Scaffolds for Bone Regeneration.
Survival of functional tissue constructs of clinically relevant size depends on the formation of an organized and uniformly distributed network of blood vessels and capillaries. The lack of such vasculature leads to spatio-temporal gradients in oxygen, nutrients and accumulation of waste products inside engineered tissue constructs resulting in negative biological events at the core of the scaf...
متن کاملHierarchically engineered fibrous scaffolds for bone regeneration.
Surface properties of biomaterials play a major role in the governing of cell functionalities. It is well known that mechanical, chemical and nanotopographic cues, for example, influence cell proliferation and differentiation. Here, we present a novel coating protocol to produce hierarchically engineered fibrous scaffolds with tailorable surface characteristics, which mimic bone extracellular m...
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ژورنال
عنوان ژورنال: Clinical Oral Implants Research
سال: 2020
ISSN: 0905-7161,1600-0501
DOI: 10.1111/clr.13_13643